Barcelona's fourth defeat of the season left them seventh in the standings on 14 points after 10 games, 12 points behind leaders Atletico.
A round-up of Wednesday's night's UEFA Chmpions League matches.
While Lyon rallied to hold Leipzig 2-2 after a Memphis Depay strike, it was the English clubs who made a mark on the night. Liverpool and Chelsea moved into the last 16 with contrasting wins and now all four English clubs, including Manchester City and Tottenham Hotspur, are in the Champions League knockouts this season.
The result also means second-placed Real Sociedad can reclaim top spot if they beat Eibar on Sunday.
Images from Wednesday's action in the UEFA Champions League.
Images from the soccer matches played across Europe on Saturday.
Real Madrid forwards Marco Asensio and Karim Benzema struck to give their side a 2-0 win at home to Eibar in La Liga
Mbappe and Benzema inspire France to 2-0 win against Finland
A summary of Tuesday's Group stage matches in the UEFA Champions League.
A summary of Wednesday's matches in the UEFA Champions League.
Images from the Champions League matches played across Europe on Tuesday
